SDF-1 and MMP2 cross talk in cancer cells and tumor microenvironment in non-small cell lung cancer

Conclusion SDF-1a directed invasion of NSCLC is mediated by crosstalk with MMP-2. The identification of SDF-1a from NSCLC tissues as a potential stimulatory factor of MMP-2 during cancer cell invasion may be involved in aggressiveness of NSCLC. Hence, identification of SDF-1a/MMP-2 interaction may implicate therapeutic approaches for metastasis from lung cancer.
Source: Egyptian Journal of Chest Diseases and Tuberculosis - Category: Respiratory Medicine Source Type: research