Reducing Vascular Calcification by Anti-IL-1{beta} Monoclonal Antibody in a Mouse Model of Familial Hypercholesterolemia

Conclusions:
Herein, we demonstrate that aortic calcifications can be inhibited by an IL-1β mAb in LDLR-deficient mice. These results have a translational component to prevent vascular calcification in human and represent new evidence to rationalize targeting inflammation in cardiovascular disease.

Source: Angiology - January 14, 2016 Category: Cardiology Authors: Awan, Z., Denis, M., Roubtsova, A., Essalmani, R., Marcinkiewicz, J., Awan, A., Gram, H., Seidah, N. G., Genest, J. Tags: Familial Hypercholesterolemia Source Type: research