Opioid growth factor and low-dose naltrexone impair central nervous system infiltration by CD4 + T lymphocytes in established experimental autoimmune encephalomyelitis, a model of multiple sclerosis

We report in these studies that the numbers of CD4+ T lymphocytes in the CNS of EAE mice are decreased following treatment with OGF for five days but not LDN. However, modulation of the OGF-OGFr axis did not result in changes to CD4+ Th effector cell responses in the CNS of EAE mice.

Source: Experimental Biology and Medicine - January 11, 2016 Category: Research Authors: Hammer, L. A., Waldner, H., Zagon, I. S., McLaughlin, P. J. Tags: Neuroscience Source Type: research