Angiotensin-(1-7) Attenuates Skeletal Muscle Fibrosis and Stiffening in a Mouse Model of Extremity Sarcoma Radiation Therapy

Conclusions:
Ang-(1-7) attenuated RIF, stiffening, and production of profibrotic cytokines that were elevated in mouse skeletal muscles after simulated radiation therapy for extremity sarcoma.

Clinical Relevance:
Ang-(1-7) may serve as a potential therapy for the prevention of RIF in patients who require radiation therapy as adjuvant treatment for soft-tissue sarcoma.

Source: The Journal of Bone and Joint Surgery - January 6, 2016 Category: Orthopaedics Authors: Willey, J. S., Bracey, D. N., Gallagher, P. E., Tallant, E. A., Wiggins, W. F., Callahan, M. F., Smith, T. L., Emory, C. L. Tags: Basic Science, Oncology Scientific Articles Source Type: research