Addition of Mesenchymal Stem Cells to Autologous Platelet-Enhanced Fibrin Scaffolds in Chondral Defects: Does It Enhance Repair?

Conclusions: APEF alone resulted in thicker repair tissue than was seen with APEF+BMDMSCs. The addition of BMDMSCs to APEF did not enhance cartilage repair and stimulated bone formation in some cartilage defects. Clinical Relevance: APEF supported repair of critical-size full-thickness chondral defects in horses, which was not improved by the addition of BMDMSCs. This work supports further investigation to determine whether APEF enhances cartilage repair in humans.

http://jbjs.org/cgi/content/short/98/1/23?rss=1

Source: The Journal of Bone and Joint Surgery - January 6, 2016 Category: Orthopaedics Authors: Goodrich, L. R., Chen, A. C., Werpy, N. M., Williams, A. A., Kisiday, J. D., Su, A. W., Cory, E., Morley, P. S., McIlwraith, C. W., Sah, R. L., Chu, C. R. Tags: Basic Science, Sports Medicine Scientific Articles Source Type: research