High signal intensity in dentate nucleus and globus pallidus on unenhanced T1‐weighted MR images in three patients with impaired renal function and vascular calcification

In conclusion, the exposure to 0.27‐0.68 mmol/kg of linear gadolinium‐based contrast agent was associated with probable gadolinium accumulation in the brain of three patients suffering from impaired renal function and vascular calcification. © 2016 The Authors. Contrast Media & Molecular Imaging published by John Wiley & Sons Ltd. We report on three patients with impaired renal function and vascular calcification (two with confirmed nephrogenic systemic fibrosis) whose unenhanced T1‐weighted MRIs showed conspicuous high signal intensity in the dentate nucleus and the globus pallidus after they had been exposed to relatively low doses of linear gadolinium‐based contrast agents (0.27, 0.45, and 0.68 mmol/kg). Of note, all three analysed patients suffered from transient signs of neurological disorders of undetermined cause.
Source: Contrast Media and Molecular Imaging - Category: Radiology Authors: Tags: Short communication Source Type: research