Impact du retard de croissance intra-utérin sur la concentration sérique maternelle du PlGF (Placental Growth Factor) : une étude cas-témoin

Conclusion Les concentrations maternelles de PlGF étaient effondrées dans le groupe RCIU par rapport à celles du groupe contrôle. Objectives Placental growth factor (PlGF) is a pro-angiogenic factor mainly assessed in preeclampsia in which its blood concentration is decreased. The aim of this study was to dose the blood concentration of PlGF in women with fetal intra-uterine growth restriction (IUGR) without associated preeclampsia at the time of diagnosis. Methods Case/control study: IUGR was defined by a fetal biometry with abnormal uterine and/or umbilical doppler (n =23). This group was compared to a control group of fetuses (n =25) matched for gestational age at blood sampling for the dosage of maternal seric PlGF. Women with preeclampsia were not included. Results The plasma PlGF concentration was 11pg/mL (IQR [11–42,8]) in the IUGR group vs 287pg/mL [135–439] in the control group (P <0.001) and this difference was available after adjustment for gestational age at the time of blood sampling (P <0.001). PlGF sensitivity and specificity for discrimination were respectively 87% (CI 95% [66–97]) and 88% (CI 95% [69–97]). Conclusion Maternal serum PlGF concentrations were very low in IUGR group compared with those of the control group.

Source: Gynecologie Obstetrique and Fertilite - January 12, 2016 Category: OBGYN Source Type: research