Cross-talk between platelet and tumor microenvironment: Role of multiligand/RAGE axis in platelet activation

While platelets are well known to play a central role in hemostasis and thrombosis, there is emerging experimental evidence to suggest that they also mediate tumor cell growth, angiogenesis and metastasis. The receptor for advanced glycation end products (RAGE) has been extensively reported in many tumor types and initiates a downstream proinflammatory signaling cascade. RAGE ligands are expressed and secreted by tumor cells and are associated with poorer outcomes in a wide variety of tumors. In addition RAGE has been identified on human platelets and RAGE ligands may contribute to platelet activation.

Source: Blood Reviews - December 16, 2015 Category: Hematology Authors: Eduardo Fuentes, Iván Palomo, Armando Rojas Tags: REVIEW Source Type: research