DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC

Disseminated intravascular coagulation (DIC) is a heterogeneous group of disorders, which manifest as a spectrum of haemorrhage and thrombosis complicating many primary conditions including sepsis, trauma and malignancies. The pathophysiology of this condition is complex. In the recent years there is growing evidence that damage associated molecular patterns (DAMPs) play a crucial role in the pathogenesis of DIC. Upon cell-death and/or cell activation of hematopoietic and parenchymal cells extracellular cell-free DNA as well as DNA binding proteins (e.g.

Source: Blood Reviews - December 30, 2015 Category: Hematology Authors: Patricia Liaw, Takashi Ito, Toshiaki Iba, Jecko Thachil, Sacha Zeerleder Tags: REVIEW Source Type: research