Mechanisms of favorable effects of Rho kinase inhibition on myocardial remodeling and systolic function after experimental myocardial infarction in the rat

Conclusions:
LV systolic dysfunction after MI was strongly associated with cardiac ROCK activation and subsequent phosphorylation of ROCK target proteins that promote ventricular remodeling such as β-MHC and the ERK/GATA-4 pathway. ROCK inhibition with fasudil significantly improved systolic function, diminished myocardial fibrosis and normalized β-MHC and ERK/GATA-4 phosphorylation levels.

Source: Therapeutic Advances in Cardiovascular Disease - January 4, 2016 Category: Cardiology Authors: Mera, C., Godoy, I., Ramirez, R., Moya, J., Ocaranza, M. P., Jalil, J. E. Tags: Original Research Source Type: research