Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment

Conclusions:
Senescent melanoma cells secret CCL5, which promotes recruitment of TILs. Combining TIS with immunotherapy that enhances tumor cell killing by TILs is a promising novel approach to improve melanoma outcomes.

Source: JNCI - December 30, 2015 Category: Cancer & Oncology Authors: Vilgelm, A. E., Johnson, C. A., Prasad, N., Yang, J., Chen, S.-C., Ayers, G. D., Pawlikowski, J. S., Raman, D., Sosman, J. A., Kelley, M., Ecsedy, J. A., Shyr, Y., Levy, S. E., Richmond, A. Tags: Article Source Type: research