Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer

Conclusions:
Inhibition of STAT1 and DUOX2-mediated ROS generation by cetuximab impairs p38-dependent apoptosis by oxaliplatin in preclinical models and may contribute to reduced efficacy in clinical settings. Understanding the rationale for unexpected trial results will inform improved rationales for combining EGFR inhibitors with chemotherapeutic agents in future therapeutic use.

Source: JNCI - December 30, 2015 Category: Cancer & Oncology Authors: Santoro, V., Jia, R., Thompson, H., Nijhuis, A., Jeffery, R., Kiakos, K., Silver, A. R., Hartley, J. A., Hochhauser, D. Tags: Article Source Type: research