Increased peri-ductal collagen micro-organization may contribute to raised mammographic density

Conclusions: These preliminary data suggest that remodelling, and hence stiffening, of the existing stromal collagen microarchitecture promotes high mammographic density within the breast. In turn, this aberrant mechanical environment may trigger neoplasia-associated mechanotransduction pathways within the epithelial cell population.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research