Increased peri-ductal collagen micro-organization may contribute to raised mammographic density
Conclusions:
These preliminary data suggest that remodelling, and hence stiffening, of the existing stromal collagen microarchitecture promotes high mammographic density within the breast. In turn, this aberrant mechanical environment may trigger neoplasia-associated mechanotransduction pathways within the epithelial cell population.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: James McConnellOliver O¿ConnellKeith BrennanLisa WeipingMiles HoweLeena JosephDavid KnightRonan O¿CualainYit LimAngela LeekRachael WaddingtonJane RoganSusan AstleyAshu GandhiCliona KirwanMichael SherrattCharles Streuli Source Type: research
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