Translating epithelial mesenchymal transition markers into the clinic: novel insights from proteomics

Publication date: Available online 6 January 2016 Source:EuPA Open Proteomics Author(s): Vergara Daniele, Simeone Pasquale, Julien Frank, Trerotola Marco, Giudetti Anna, Capobianco Loredana, Tinelli Andrea, Bellomo Claudia, Fournier Isabelle, Antonio Gaballo, Alberti Saverio, Salzet Michel, Maffia Michele The growing understanding of the molecular mechanisms underlying epithelial-to-mesenchymal transition (EMT) may represent a potential source of clinical markers. Despite EMT drivers have not yet emerged as candidate markers in the clinical setting, their association with established clinical markers may improve their specificity and sensitivity. Mass spectrometry-based platforms allow analyzing multiple samples for the expression of EMT candidate markers, and may help to diagnose diseases or monitor treatment efficiently. This review highlights proteomic approaches applied to elucidate the differences between epithelial and mesenchymal tumors and describes how these can be used for target discovery and validation. Graphical abstract

Source: EuPA Open Proteomics - January 11, 2016 Category: Bioinformatics Source Type: research