Molecular mechanisms of curcumins suppressing effects on tumorigenesis, angiogenesis and metastasis, focusing on NF-κB pathway

Changes in function of transcription factors, a group of molecules with regulatory roles in cells, have shown to be involved in several steps of carcinogenesis including tumorigenesis, angiogenesis and metastasis. These changes are together with activation or secretion of several oncogenes and cytokines, forming a positive feedback, pushing further the tumorigenesis process. In addition, many other factors including UV/Gamma irradiation and free radicals can accelerate tumor formation process too.
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research