The cytokine-serum amyloid A-chemokine network

During inflammatory events, such as infection, trauma and neoplasia, the acute phase response is initiated to eliminate pathogens and to restore homeostasis without causing too much damage to the organism. This acute phase response is characterized by a wide range of systemic and metabolic changes (e.g., fever, leukocytosis, altered plasma levels of minerals and vitamins), including the induction of acute phase proteins (e.g., serum amyloid A, C-reactive protein) in the liver [1,2]. In humans, serum amyloid A (SAA) is one of the major acute phase proteins and consists of SAA1, SAA2, SAA3 and SAA4.

Source: Cytokine and Growth Factor Reviews - December 27, 2015 Category: Molecular Biology Authors: Mieke De Buck, Mieke Gouwy, Ji Ming Wang, Jacques Van Snick, Paul Proost, Sofie Struyf, Jo Van Damme Tags: Survey Source Type: research