Fenoldopam to prevent acute kidney injury after major surgery—a systematic review and meta-analysis
Conclusions:
In this analysis, peri-operative treatment with fenoldopam was associated with a significant reduction in post-operative AKI but it had no impact on renal replacement therapy or hospital mortality. Equipoise remains for further large trials in this area since the studies were conducted in three types of surgery, the majority of studies were rated at high risk of bias and the criteria for AKI varied between trials.
Source: Epidemiologic Perspectives and Innovations - Category: Epidemiology Authors: Michael GilliesVivek KakarRobert ParkerPatrick HonoréMarlies Ostermann Source Type: research