Calreticulin activates {beta}1-integrin through fucosylation modification by fucosyltransferase-1 in J82 human bladder cancer cells

In conclusion, our findings suggested that CRT stabilized FUT1 mRNA, thereby leading to increase in fucosylation of β1-integrin. Furthermore, increased fucosylation levels activate β1-integrin rather than directly modifying the integrin binding sites.

Source: BJ Cell - March 4, 2014 Category: Biochemistry Authors: Y Lu, C Chen, C Chu, J Lu, B Wang, C Chen, M Huang, T Lin, C Pan, S Alex Chen, W Hsu, Y Liao, P Wu, H Hsia, C Chang, H Lee Tags: BJ Biomolecules Source Type: research