Challenges in circulating tumor cell detection by the CellSearch system
Enumeration and characterization of circulating tumor cells (CTC) hold the promise of a real time liquid biopsy. They are however present in a large background of hematopoietic cells making their isolation technically challenging. In 2004, the CellSearch system was introduced as the first and only FDA cleared method designed for the enumeration of circulating tumor cells in 7.5 mL of blood. Presence of CTC detected by CellSearch is associated with poor prognosis in metastatic carcinomas. CTC remaining in patients after the first cycles of therapy indicates a futile therapy.
Source: Molecular Oncology - Category: Cancer & Oncology Authors: Kiki C. Andree, Guus van Dalum, Leon WMM. Terstappen Tags: Review Source Type: research
More News: Cancer & Oncology | Carcinoma