Aldosterone effects on glomerular structure and function

Conclusions:
Aldosterone damages not only the structure but also the function of the glomerulus. ACE/ACE2 upregulation, ACE2 and ANP downregulation, and pro-oxidative and profibrotic changes are possible mechanisms accounting for aldosterone-induced glomerular injury.

Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Bernardi, S., Toffoli, B., Zennaro, C., Bossi, F., Losurdo, P., Michelli, A., Carretta, R., Mulatero, P., Fallo, F., Veglio, F., Fabris, B. Tags: Original Articles Source Type: research