Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer’s disease
IntroductionNeuroinflammation and synaptic degeneration are major neuropathological hallmarks in Alzheimer’s disease (AD). Neurogranin and YKL-40 in cerebrospinal fluid (CSF) are newly discovered markers indicating synaptic damage and microglial activation, respectively.
Methods:
CSF samples from 95 individuals including 39 patients with AD dementia (AD-D), 13 with mild cognitive impairment (MCI) due to AD (MCI-AD), 29 with MCI not due to AD (MCI-o) and 14 patients with non-AD dementias (non-AD-D) were analyzed for neurogranin and YKL-40.
Results:
Patients with dementia or MCI due to AD showed elevated levels of CSF neurogranin (p
Source: Epidemiologic Perspectives and Innovations - Category: Epidemiology Authors: Konstantin HellwigHlin KvartsbergErik PorteliusUlf AndreassonTimo ObersteinPiotr LewczukKaj BlennowJohannes KornhuberJuan MalerHenrik ZetterbergPhilipp Spitzer Source Type: research