Integrated analysis of the prostate cancer small-nucleolar transcriptome reveals as a driver of prostate cancer progression

Metastasis is the primary cause of death in prostate cancer (PCa) patients. Small nucleolar RNAs (snoRNAs) have long been considered “housekeeping” genes with no relevance for cancer biology. Emerging evidence has challenged this assumption, suggesting that snoRNA expression is frequently modulated during cancer progression. Despite this, no study has systematically addressed the prognostic and functional significance of snoRNAs in PCa.We performed RNA Sequencing on paired metastatic/non-metastatic PCa xenografts derived from clinical specimens.

Source: Molecular Oncology - December 21, 2015 Category: Cancer & Oncology Authors: Francesco Crea, Luca Quagliata, Agnieszka Michael, Hui Hsuan Liu, Paolo Frumento, Arun A. Azad, Hui Xue, Larissa Pikor, Akira Watahiki, Rudolf Morant, Serenella Eppenberger-Castori, Yuwei Wang, Abhijit Parolia, Kim A. Lennox, Wan L. Lam, Martin Gleave, Ki Source Type: research