Engineering of radiolabeled iron oxide nanoparticles for dual‐modality imaging

Over the last decade, radiolabeled iron oxide nanoparticles have been developed as promising contrast agents for dual‐modality positron emission tomography/magnetic resonance imaging (PET/MRI) or single‐photon emission computed tomography/magnetic resonance imaging (SPECT/MRI). The combination of PET (or SPECT) with MRI can offer synergistic advantages for noninvasive, sensitive, high‐resolution, and quantitative imaging, which is suitable for early detection of various diseases such as cancer. Here, we summarize the recent advances on radiolabeled iron oxide nanoparticles for dual‐modality imaging, through the use of a variety of PET (and SPECT) isotopes by using both chelator‐based and chelator‐free radiolabeling techniques.
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - Category: Nanotechnology Authors: Tags: Advanced Review Source Type: research