First Step-by-Step Snapshots of Transcription Initiation

When a gene is turned on--such as insulin in pancreatic cells or melanin in skin cells--an enzyme called RNA polymerase transcribes the genetic information from DNA into RNA. But RNA polymerase can’t initiate the process alone. A bevy of helper molecules identify the gene’s start site, provide a landing pad for the polymerase and prime the DNA for transcription. These helpers alight onto the DNA and assemble into a growing complex in a precise, stepwise manner that has now been captured in a series of detailed molecular snapshots. Knowing how this intricate complex forms provides a valuable framework for understanding malfunctions that cause cancer and other medical problems.
Source: NIGMS Biomedical Beat - Category: Research Source Type: news