The transcription factors slug (snai2) and snail (snai1) regulate phospholipase d (pld) promoter in opposite ways towards cancer cell invasion

Slug (SNAI2) and Snail (SNAI1) are master regulatory transcription factors for organogenesis and wound healing, and they are involved in the epithelial-mesenchymal transition (EMT) of cancer cells. We found that the activity of phospholipase D isoform 2 (PLD2) is highly increased in cancers with larger size and poor prognosis (MDA-MB-231 vs. MCF-7 cells), so we determined if Snail or Slug were responsible for PLD2 gene transcription regulation. Unexpectedly, we found that PLD2 expression was positively regulated by Slug but negatively regulated by Snail.
Source: Molecular Oncology - Category: Cancer & Oncology Authors: Source Type: research