AGR2 oncoprotein inhibits p38MAPK and p53 activation through a DUSP10-mediated regulatory pathway

The tumor suppressor p53 plays a key role in malignant transformation and tumor development. However, the frequency of p53 mutations within individual types of cancer is different, suggesting the existence of other mechanisms attenuating p53 tumor suppressor activity. Changes in upstream regulators of p53 such as MDM2 amplification and overexpression, expression of viral oncoproteins, estrogen receptor signaling, or changes in p53 transcriptional target genes were previously described in wild-type p53 tumors.

Source: Molecular Oncology - December 16, 2015 Category: Cancer & Oncology Authors: Roman Hrstka, Pavla Bouchalova, Eva Michalova, Eva Matoulkova, Petr Muller, Philip J. Coates, Borivoj Vojtesek Source Type: research