Secretory leukocyte protease inhibitor (SLPI), a multifunctional protein in the host defense response

Secretory leukocyte protease inhibitor (SLPI), a member of the whey acidic protein family [1], is a key contributor to the host’s antiprotease screen, primarily in mucosal secretions [2]. The most important defining feature of SLPI is its inhibition of serine proteases, including elastase and cathepsin G from human neutrophils, and of mast cell-derived chymase and tryptase [3–6]. This inhibitor is mainly found as a secretory product of epithelial cells but is also produced by host-defense effector cells [7–18].

Source: Cytokine and Growth Factor Reviews - December 16, 2015 Category: Molecular Biology Authors: Monika Majchrzak-Gorecka, Pawel Majewski, Beata Grygier, Krzysztof Murzyn, Joanna Cichy Tags: Survey Source Type: research