Viscosupplementation for Osteoarthritis of the Knee: A Systematic Review of the Evidence

Conclusions: Meta-analysis of only the double-blinded, sham-controlled trials with at least sixty patients did not show clinically important differences of HA treatment over placebo. When all literature was added to the analysis, the overall effect was greater but was biased toward stronger treatment effects because of the influence of nonblinded or improperly blinded trials. Level of Evidence: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Source: The Journal of Bone and Joint Surgery - Category: Orthopaedics Authors: Tags: Knee Evidence-Based Orthopaedics Source Type: research