An Independent Evaluation of the Validity of a DNA-Based Prognostic Test for Adolescent Idiopathic Scoliosis

Conclusions:
ScoliScores did not differ between patients with and without curve progression, and the negative and positive predictive values were lower in our study than in the previously published validation study by the developers of the test. This may be due to differences in our test population, genetic variability, or failure of patients in the non-progression group to follow up.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

Source: The Journal of Bone and Joint Surgery - December 16, 2015 Category: Orthopaedics Authors: Roye, B. D., Wright, M. L., Matsumoto, H., Yorgova, P., McCalla, D., Hyman, J. E., Roye, D. P., Shah, S. A., Vitale, M. G. Tags: Pediatrics, Spine Scientific Articles Source Type: research