A high-fat diet increases body weight and circulating estradiol concentrations but does not improve bone structural properties in ovariectomized mice

The objective of the study was to determine whether high-fat diet induced obesity affects bone structure and alters markers of bone turnover in ovariectomized (OVX) mice. We hypothesized that a high-fat diet would increase body weight gain and serum estradiol levels in OVX mice but would not improve bone structural parameter in OVX mice. Thirty-five C57BL/6 mice were either sham-operated or OVX at age of 4 mo and then fed either a normal-fat diet (10% kcal as fat) or a high-fat diet (45% kcal as fat with extra fat from lard) ad libitum for 11 wks.
Source: Nutrition Research - Category: Nutrition Authors: Tags: Original Research Source Type: research