Beta cell glucose sensitivity is linked to insulin/glucagon bihormonal cells in non-diabetic humans.

CONCLUSIONS: Our data suggest that poor β-cell glucose sensitivity is linked to islet trans-differentiation, possibly from α cells to β cells, in an attempt to cope with higher demands for insulin secretion. Understanding the mechanism(s) that underlies the adaptive response of the islet cells to insulin resistance is a potential approach to design tools to enhance functional β-cell mass for diabetes therapy.
PMID: 26649619 [PubMed - as supplied by publisher]

Source: Diabetes Metab - December 9, 2015 Category: Endocrinology Authors: Mezza T, Sorice GP, Conte C, Sun VA, Cefalo CM, Moffa S, Pontecorvi A, Mari A, Kulkarni RN, Giaccari A Tags: J Clin Endocrinol Metab Source Type: research