Heart failure is associated with exaggerated endothelial ischaemia-reperfusion injury and attenuated effect of ischaemic preconditioning

Conclusion
We found that patients with heart failure are associated with exaggerated endothelial IR-injury compared with age- and sex-matched, healthy controls, which may contribute to the poor clinical prognosis in heart failure. Furthermore, we found no protective effect of ischaemic preconditioning (3 x 5-min forearm ischaemia) against endothelial IR-injury in heart failure patients.

Source: European Journal of Preventive Cardiology - December 11, 2015 Category: Cardiology Authors: Seeger, J. P., Benda, N. M., Riksen, N. P., van Dijk, A. P., Bellersen, L., Hopman, M. T., Cable, N. T., Thijssen, D. H. Tags: Original scientific papers Source Type: research