Circulating Adiponectin Concentrations are Increased by Dietary Resistant Starch and Correlate with Serum 25-Hydroxycholecalciferol Concentrations and Kidney Function in Zucker Diabetic Fatty Rats

We previously reported that dietary resistant starch type 2 (RS) prevented proteinuria and promoted vitamin D balance in type 2 diabetic (T2D) rats. Here, our primary objective was to identify potential mechanisms that could explain our earlier observations. We hypothesized that RS could promote adiponectin secretion and regulate the renin-angiotensin system activity in the kidney. Lean Zucker rats (n=5) were fed control diet (LC); Zucker diabetic fatty (ZDF) rats (n = 5/group) were fed either an AIN-93G control diet (DC), or AIN-93G diet containing either 10% RS (MRS) or 20% RS (HRS) for 6 wks.

Source: Nutrition Research - December 8, 2015 Category: Nutrition Authors: Gar Yee Koh, Rachel Derscheid, Kelly N.Z. Fuller, Rudy J. Valentine, Shu En Leow, Leah Reed, Emily Wisecup, Kevin L. Schalinske, Matthew J. Rowling Source Type: research