Identification and biological consequences of the O-GlcNAc modification of the human innate immune receptor, Nod2

The objective of this study is to further characterize this protein by determining whether Nod2 is posttranslationally modified by O-N-acetylglucosamine (O-GlcNAc). O-GlcNAcylation is one type of posttranslational modification in which the O-GlcNAc transferase transfers GlcNAc from UDP-GlcNAc to selected serine and threonine residues of intracellular proteins. We found that wild-type Nod2 and a Nod2 Crohn's-associated variant are O-GlcNAcylated and this modification affects Nod2's ability to signal via the nuclear factor kappa B pathway.

Source: Glycobiology - December 7, 2015 Category: Biology Authors: Hou, C.-W., Mohanan, V., Zachara, N. E., Grimes, C. L. Tags: Immunology Source Type: research