Long-term ketogenic diet contributes to glycemic control but promotes lipid accumulation and hepatic steatosis in type 2 diabetic mice

In this study, we hypothesized that the KD would ameliorate the progression of diabetes, but lead to disruptions in lipid metabolism and hepatic steatosis in a mouse model of diabetes. A type 2 diabetic mouse model fed a high-fat diet (HFD) and administered streptozotocin treatment before given the test diets for eight weeks. Subsequently, ameliorated glucose and insulin tolerance in KD-fed diabetic mice was found, although the body weight of HFD and KD-fed mice was similar.
Source: Nutrition Research - Category: Nutrition Authors: Source Type: research