Histone H2AX and the small RNA pathway modulate both non-homologous end-joining and homologous recombination in plants

Publication date: Available online 4 December 2015 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Yiping Qi, Yong Zhang, Joshua A. Baller, Daniel F. Voytas Using a zinc finger nuclease (ZFN) that creates a site-specific DNA double-strand break (DSB) at the endogenous ADH1 locus, we provide genetic evidence that histone H2AX and DSB-induced small RNAs modulate DNA repair by both non-homologous end-joining (NHEJ) and homologous recombination (HR) in the model plant Arabidopsis thaliana .
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - Category: Cytology Source Type: research