Uremic parkinsonism with atypical phenotypes and radiologic features.

Uremic parkinsonism with atypical phenotypes and radiologic features.
Metab Brain Dis. 2015 Dec 3;
Authors: Yoon JE, Kim JS, Park JH, Lee KB, Roh H, Park ST, Cho JW, Ahn MY
Abstract
Uremic encephalopathy with bilateral basal ganglia lesions has been reported as an acute neurometabolic disease which shows reversible clinical course and brain imaging features. The exact nature and pathophysiology have not been well established. We encountered two patients who showed a relapsing and aggravating course and an atypical phenotype including parkinsonism with paroxysmal dystonic head tremor and acute onset monoparesis of the lower extremity. They also showed unusual radiological findings which revealed combined lesions in the basal ganglia and cortex, persistent hemorrhagic transformation, and focal ischemic lesion in the internal capsule. Herein, we present the unusual phenomenology with atypical radiologic findings and suggest the possible multifactorial pathogenesis of uremic encephalopathy.
PMID: 26631408 [PubMed - as supplied by publisher]

Source: Diabetes Metab - December 3, 2015 Category: Endocrinology Authors: Yoon JE, Kim JS, Park JH, Lee KB, Roh H, Park ST, Cho JW, Ahn MY Tags: Metab Brain Dis Source Type: research