Asymmetric Morita-Baylis-Hillman Reaction Catalyzed by Pepsin

Publication date: Available online 4 December 2015 Source:Journal of Molecular Catalysis B: Enzymatic Author(s): Jing-Wen Xue, Jian Song, Ian C.K. Manion, Yan-Hong He, Zhi Guan Pepsin from porcine gastric mucous shown catalytic promiscuity was first discovered to catalyze the Morita-Baylis-Hillman (MBH) reaction between aromatic aldehydes with 2-cyclohexen-1-one or 2-cyclopenten-1-one in a two-phase medium of phosphate buffer/cyclohexane in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO). The best results of the corresponding MBH products up to 77% yield and 38% ee were achieved. Graphical abstract
Source: Journal of Molecular Catalysis B: Enzymatic - Category: Biochemistry Source Type: research