Dual inhibition of Type I and Type III PI3 kinases increases tumor cell apoptosis in HER2+ breast cancers

Conclusions: These studies highlight the important role of Vps34-mediated autophagy in limiting the anti-tumor response to inhibitors of HER2 or type I PI3K in HER2+ breast cancers. The type III PI3K Vps34 represents a potential therapeutic target to block treatment-induced autophagy and enhance tumor cell killing.

http://breast-cancer-research.com/content/17/1/148

Source: Breast Cancer Research - December 4, 2015 Category: Cancer & Oncology Authors: Christian YoungCarlos ArteagaRebecca Cook Source Type: research