Tuning cellular responses to BMP-2 with material surfaces

Bone morphogenetic protein 2 (BMP-2) is a multifunctional growth factor belonging to the transforming growth factor β (TGF-β) superfamily. It was identified in the 1970s as an essential molecule for de novo bone formation in adult animals [1,2]. Indeed BMP-2 is one of the strongest osteoinductive factors known so far: it initiates the differentiation of mesenchymal stem cells (MSCs) into osteoblasts and chondrocytes in vivo and in vitro [3], as well as the transdifferentiation of muscle cells into bone cells [4,5].
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Survey Source Type: research