Effect of lipid rescue therapy on laboratory tests

3 out of 5 stars Review of the effect of intravenous lipid emulsion on laboratory analyses. Grunbaum AM et al. Clin Toxicol 2015 Dec 1 [Epub ahead of print] Abstract Lipemic serum can interfere with laboratory measurements because of a number of factors: sample turbidity, partitioning, and cross-reactivity. Clinicians who are not aware of these effects can be misled by erroneous lab results in ways that may affect patient management. The Lipid Emulsion Therapy in Clinical Toxicology Workgroup was established by the American Academy of Clinical Toxicology to “review all appropriate evidence pertaining to the use of lipid emulsion in toxicology, with the ultimate goal of providing evidence and consensus-based recommendations.” This paper — written by a selected members of the workgroup — reviews the literature regarding the effect of lipid emulsion [LE] on laboratory analyses. The paper is heavy on biochemical techniques, making it a somewhat difficult read for clinicians. In addition, as the authors point out, the effects of LE on laboratory tests depends on specific techniques and manufacturers, making the entire topic somewhat of a moving target. However, there are several important take-home points: Clinicians should be aware administration of LE can alter lab results. When possible, a blood sample should be obtained before administration of LE to provide baseline values. After administration of LE, the clinician should communicate with the laboratory t...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical intralipid laboratory interference lipid emulsion lipid rescue therapy Source Type: news