Interleukin-10 gene-carrying bifidobacteria ameliorate murine ulcerative colitis by regulating regulatory T cell/T helper 17 cell pathway

In conclusion, oral administration of BL-hIL-10 can alleviate the inflammation responses of UC in murine model through the restoration of Treg/Th17 imbalance, which might be at least partially due to the inhibition of hypoxia–mTOR–HIF-1α–Th17 axis as well as IL-6–STAT3–HIF-1α–Th17 pathway.

Source: Experimental Biology and Medicine - December 2, 2015 Category: Research Authors: Zhang, D., Wei, C., Yao, J., Cai, X., Wang, L. Tags: Biochemistry & amp;amp; Molecular Biology Source Type: research