Angiotensin II increases matrix metalloproteinase 2 expression in human aortic smooth muscle cells via AT1R and ERK1/2

In conclusion, these results indicate that Ang II can increase the expression of MMP-2 via AT1 receptor and ERK1/2 signaling pathways in human ASMCs and suggest that antagonists of AT1R and ERK1/2 may be useful for treating TAAs.

Source: Experimental Biology and Medicine - December 2, 2015 Category: Research Authors: Wang, C., Qian, X., Sun, X., Chang, Q. Tags: Biochemistry & amp;amp; Molecular Biology Source Type: research