Polymorphisms in the P1 promoter of the IGF-1 gene in children with growth disorders.

CONCLUSIONS: This study demonstrated that SNP and (CA) n microsatellite repeat polymorphisms by themselves are not the primary regulatory elements of IGF-1 expression. However, our bioinformatics analysis has shown that the (CA) n microsatellite region in the P1 promoter of IGF-1 is able to form DNA loop structures which can modulate transcription.
PMID: 26615580 [PubMed - in process]

Source: Diabetes Metab - December 2, 2015 Category: Endocrinology Authors: Broniarczyk JK, Kędzia A, Nowak W, Kościński Ł, Lewandowski M, Goździcka-Józefiak A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research