hnRNPA2/B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers

Cyclooxygenase-2 (COX-2) is highly expressed in tumor cells and has been regarded as a hallmarker for cancers, but the excise regulation mechanism of COX-2 in tumorigenesis remains largely unknown. Here, we pulled down and identified a novel COX-2 regulator, heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1), which could specifically bind to COX-2 core promoter and regulate tumor growth in non-small-cell lung cancers (NSCLCs). Knockdown of hnRNPA2/B1 by shRNA or siRNA downregulated COX-2 expression and prostaglandin E2 (PGE2) production, and suppressed tumor cell growth in NSCLC cells in vitro and in vivo.

Source: Molecular Oncology - November 30, 2015 Category: Cancer & Oncology Authors: Yang Xuan, Liying Ban, Jian-Jun Lu, Xiangsheng Xiao, Canhui Yi, Zhenglin Li, Wendan Yu, Mei Li, Tingting Xu, Wenjing Yang, Zhipeng Tang, Ranran Tang, Qianyi Zhang, Songshu Meng, Bilian Jin, Quentin Liu, Wenlin Huang, Wei Guo, Xiaonan Cui, Wuguo Deng Source Type: research