Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury

This 12-center open-label pilot trial of critically ill adults with volume replete severe AKI randomized atients were randomized to accelerated (12 h or less from eligibility) or standard RRT initiation. The enrollment median serum creatinine was 268 micromoles/l and urine output was 356 ml per 24 h. Clinical outcomes at 90 days included mortality which was 38% in the accelerated and 37% in the standard arm. The feasibility and findings of this study can be used to inform a large-scale effectiveness randomized control trial. : The Hannover Dialysis Outcome study: comparison of standard versus intensified extended dialysis for treatment of patients with acute kidney injury in the intensive care unit Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis.
Source: Nephrology Now - Category: Urology & Nephrology Authors: Tags: Acute Kidney Injury Clinical Nephrology Clinical Trial Results Source Type: research