Helicobacter pylori, cyclooxygenase-2 and evolution of gastric lesions: results from an intervention trial in China

To investigate the role of cyclooxygenase (COX)-2/prostaglandin E2 (PGE2) in the process of Helicobacter pylori-induced gastric carcinogenesis, a prospective study based on an intervention trial was conducted in Linqu County, China. A total of 1401 subjects with histopathologic diagnosis were investigated at baseline, among those, 919 completed subsequent interventions (anti-H.pylori and/or celecoxib treatment). Expressions of COX-2 and Ki-67 were assessed by immunohistochemistry, and PGE2 levels were measured by enzyme immunoassay before and after interventions, respectively. We found a grade–response relationship between COX-2 expression level and risk of advanced gastric lesions at baseline. Stratified analysis indicated an additive interaction between COX-2 expression and H.pylori infection on the elevated risk of advanced gastric lesions. The odds ratios (ORs) for both factors combined were 9.31 [95% confidence interval (CI): 4.13–20.95] for chronic atrophic gastritis, 16.26 (95% CI: 7.29–36.24) for intestinal metaplasia and 21.13 (95% CI: 7.87–56.75) for dysplasia, respectively. After interventions, COX-2 expression and Ki-67 labeling index (LI) were decreased in anti-H.pylori group (OR: 1.65, 95% CI: 1.36–1.99 for COX-2; OR: 1.78, 95% CI: 1.49–2.12 for Ki-67) or anti-H.pylori followed by celecoxib group (OR: 1.41, 95% CI: 1.17–1.70 for COX-2; OR: 1.63, 95% CI: 1.37–1.94 for Ki-67). PGE2 levels were decreased in all treatm...

Source: Carcinogenesis - November 28, 2015 Category: Cancer & Oncology Authors: Zhang, Y., Pan, K.-f., Zhang, L., Ma, J.-l., Zhou, T., Li, J.-y., Shen, L., You, W.-c. Tags: Original Manuscript Source Type: research