MicroRNA-218 is a prognostic indicator in colorectal cancer and enhances 5-fluorouracil-induced apoptosis by targeting BIRC5

In conclusion, we demonstrated that high miR-218 expression had a positive prognostic value in 5-FU-based treatments for CRC patients and discovered a novel mechanism mediated by miR-218 to promote apoptosis and to function synergistically with 5-FU to promote chemosensitivity by suppressing BIRC5 and TS in CRC. These suggest the unique potential of miR-218 as a novel candidate for developing miR-218-based therapeutic strategies in CRC.

Source: Carcinogenesis - November 28, 2015 Category: Cancer & Oncology Authors: Li, P.-L., Zhang, X., Wang, L.-L., Du, L.-T., Yang, Y.-M., Li, J., Wang, C.-X. Tags: Original Manuscript Source Type: research