Effects of tramadol, clonazepam, and their combination on brain mitochondrial complexes

In conclusion, tramadol but not clonazepam has been found to partially inhibit the activities of respiratory chain complexes I, III, and IV but not the activity of complex II and such inhibition occurred only at doses that exceeded the maximum recommended adult human daily therapeutic doses. This result explains the clinical and histopathological effects of tramadol, such as seizures and red neurons (marker for apoptosis), respectively.
Source: Toxicology and Industrial Health - Category: Toxicology Authors: Tags: Articles Source Type: research