Mechanisms of cisplatin resistance and targeting of cancer stem cells: Adding glycosylation to the equation

Cisplatin-based chemotherapeutic regimens are the most frequently used (neo)adjuvant treatments for the majority of solid tumors. While platinum-based chemotherapeutic regimens have proven effective against highly proliferative malignant tumors, significant relapse and progression rates as well as decreased overall survival are still observed. Currently, it is known that sub-populations of chemoresistant cells share biological properties with cancer stem cells (CSC), which are believed to be responsible for tumor relapse, invasion and ultimately disease dissemination through acquisition of mesenchymal cell traits.

Source: Drug Resistance Updates - November 25, 2015 Category: Drugs & Pharmacology Authors: José Alexandre Ferreira, Andreia Peixoto, Manuel Neves, Cristiana Gaiteiro, Celso A. Reis, Yehuda G. Assaraf, Lúcio Lara Santos Source Type: research